（2023年10月2日）- IVERMECTIN和癌症，它至少具有15种抗癌作用机制。Ivermectin能治疗COVID-19 mRNA疫苗诱导的Turbo癌症吗？- 综述了9篇Ivermectin论文

 

本文（第2部分）的目标是尽我所能回答所有这些问题。

 

First, dose safety. Can you overdose on Ivermectin? Not really.

首先，剂量安全性。您可以过量使用Ivermectin吗？实际上不能。

Safety of 18mg and 36mg single dose regimens: (2018, Munoz et al)

18毫克和36毫克单剂方案的安全性：（2018年，Munoz等人）

• Safety data showed no significant differences between groups and no serious adverse events: headache was the most frequent adverse event in all treatment groups, none of them severe.

  安全数据显示，各组之间没有显著差异，也没有严重不良事件：头痛是所有治疗组中最常见的不良事件，但没有一例是严重的。

• “highlighting its safety across different dosing regimens.”

  “强调了它在不同剂量方案下的安全性。”

Safety of 30 or 60mg (3 times a week) or 90 or 120mg (single dose) (2002, Guzzo et al)

30或60毫克（每周3次）或90或120毫克（单剂量）的安全性（2002年，Guzzo等人）

• Ivermectin was generally well tolerated, with no indication of associated CNS toxicity for doses up to 10 times the highest FDA-approved dose of 200 microg/kg.

  Ivermectin通常耐受良好，没有显示与剂量高达美国食品药品监督管理局批准的最高剂量200微克/千克相关的中枢神经系统毒性的迹象。

• Following single doses of 30 to 120 mg, AUC and Cmax were generally dose proportional, with t(max) approximately 4 hours and t1/2 approximately 18 hours

  在30至120毫克的单剂量后，AUC和Cmax通常与剂量成比例，t(max)约为4小时，t1/2约为18小时。

• This study demonstrated that ivermectin is generally well tolerated at these higher doses and more frequent regimens.

  该研究表明，ivermectin通常在这些较高剂量和更频繁的方案下耐受良好。

Safety of 1mg/kg dose for 180 days (2020 de Castro et al)

1mg/kg剂量180天的安全性（2020年de Castro等人）

• “Cancer patients who took ivermectin at five times that standard dose daily for up to 180 consecutive days had no serious adverse effects from it, in experimental protocols with harsh additional drugs”

  “癌症患者每天服用ivermectin的标准剂量的五倍，连续180天，没有严重不良影响，即使在使用严酷的附加药物的实验方案中也是如此。”

Safety of 800ug/kg (2020, Navarro et al)

800ug/kg的安全性（2020年，Navarro等人）

• “add evidence to the safety of ivermectin at doses up to 800 μg/kg, which demonstrated an overall comparable safety to standard doses, which in this meta-analysis was tested in separate analyses using the 200 and 400 μg/kg doses”

  “增加了有关ivermectin在剂量高达800μg/kg时的安全性的证据，这表明与标准剂量的总体安全性相当，在这个荟萃分析中，标准剂量通过使用200和400μg/kg剂量进行了单独分析”

Safety of 2mg/kg dose (Jonathan Lee, critical care paramedic in Toronto Canada)

2mg/kg剂量的安全性（Jonathan Lee，多伦多加拿大的重症监护医护人员）

“The human data surrounding ivermectin overdose is limited. Animal models generally report doses between 5-15 mg/kg as toxic. Poison control suggests individuals who have received more than 2 mg/kg be seen in a hospital. It is with larger doses that Ivermectin is able to cross the blood-brain barrier in humans and begin to cause neurological symptoms.”

“有关ivermectin过量的人体数据有限。动物模型通常报告5-15毫克/千克剂量为有毒。毒物控制建议接受超过2毫克/千克的个体去医院就诊。仅在较大剂量下，ivermectin才能穿过人类的血脑屏障，并开始引起神经系统症状。”

 

FORMULATIONS:

配方：

I don’t recommend brands or sell Ivermectin or recommend particular suppliers! Get the formulation or brand that is right for you.

我不建议特定品牌或销售Ivermectin，也不推荐特定供应商！选择适合您的配方或品牌。

Some common formulations that are available on the market:

市场上常见的一些配方包括：

• pills or tablets typically come in 3mg, 6mg or 12mg

• 药丸或片剂通常是3毫克、6毫克或12毫克。

• liquid form is usually 1mL per 10mg of IVM (always double check)

• 液体形式通常是每1毫升10毫克的Ivermectin（请务必双重检查）。

• paste form is usually 6.4g per 120mg of IVM (always double check)

• 膏剂形式通常是每120毫克Ivermectin的6.4克（请务必双重检查）。

 

 

EXPERIMENTAL CANCER PROTOCOLS:

实验性癌症方案：

I propose the following thought experiment & hypothetical “Experimental Protocols” for Turbo Cancer Treatment:

我提出以下的思想实验和假设性的“实验方案”用于涡轮癌症治疗：

Dr.Makis’ Ivermectin Cancer Protocols:

马基斯博士的Ivermectin癌症方案：

中文翻译：

 

How this works with the various formulations of Ivermectin:

如何与各种Ivermectin配方配合使用：

Assume a 60kg person is diagnosed with Stage 4 Turbo Colon Cancer.

假设一个60公斤的人被诊断出患有四期涡轮结肠癌。

And this person wants to take a 1mg/kg/day regimen. That’s 60mg of IVM per day.

而这个人想要采取每日1mg/kg的方案。这就是每天60mg的Ivermectin。

That would be five 12mg pills a day. Or 150 12mg pills a month. This can get very expensive, especially if the cost of pills is anywhere from $2 to $5 per pill.

这将是每天五片12mg的药丸。或每月150片12mg的药丸。这可能非常昂贵，特别是如果药丸的价格在每片2美元至5美元之间。

Alternatively, it would be 6mL of IVM liquid (10mg/1mL) per day.

另一种选择是每天6毫升的Ivermectin液体（10毫克/1毫升）。

Alternatively, it would be 3g or half a tube of paste per day.

另一种选择是每天3克或半管Ivermectin膏。

If cost is an issue, the cheapest would be the liquid, which is typically $100 per 500mL or $1 per 5mL, or about $1 per day.

如果费用是一个问题，最便宜的选择是液体，通常是每瓶500毫升100美元，或每5毫升1美元，大约每天1美元。

A tube of paste would be $10 per 6g, and half would be $5 per day.

一管膏是每支10美元，半支是每天5美元。

Five 12mg pills a day would be anywhere from $10 to $25 per day.

每天五片12mg的药丸的费用可能在10美元至25美元之间。

The cost of pills varies widely, depending on where you obtain them. Most people import them from India but they can still be pricy. I was in Mexico recently and over the counter 6mg pills were $5 USD each (a ridiculous price so I didn’t buy, but it was a small pharmacy in a very Tourist area).

药丸的价格因来源不同而有很大差异。大多数人从印度进口，但它们仍然可能很贵。我最近在墨西哥，非处方的6毫克药丸每片售价5美元（价格太离谱了，所以我没有买，但那是一个非常旅游的地区的一个小药房）。

 

LOW DOSE:

低剂量：

Some people want to take Ivermectin prophylactically to protect themselves in these types of situations:

有些人想要预防性地服用Ivermectin来保护自己免受这些情况的影响：

• Cancer in remission

  癌症缓解期

• Strong family history of Cancer

  家族中有癌症强烈的历史

• Genetic predisposition to cancer

  对癌症的遗传易感性

In these cases a low dose would be 12mg or 24mg a day and would be considered prophylaxis. There are currently no studies looking at Ivermectin taken as prophylaxis to protect against cancer.

在这些情况下，低剂量将是每天12mg或24mg，并被视为预防性。目前没有研究证明Ivermectin作为预防措施来保护免受癌症的影响。

Would you get protection against cancer? I believe you would.

你会获得对癌症的保护吗？我相信会。

 

MEDIUM DOSE:

中剂量：

1mg/kg/day seems to be a reasonable starting dose for most cancer cases.

每天1mg/kg似乎是大多数癌症病例的合理起始剂量。

You would not expect any side effects at this dose and finacially, it can be accomplished very affordably.

在这个剂量下，你不会期望出现任何副作用，而且从财务上讲，这个剂量非常经济。

When you can monitor tumor burden with a blood test for cancers like prostate cancer (PSA), colon cancer (CEA) or ovarian cancer (CA125), it’s very important to measure these on a regular basis and watch the numbers drop over time.

当您可以通过血液测试来监测肿瘤负担，如前列腺癌（PSA）、结肠癌（CEA）或卵巢癌（CA125）时，定期测量这些数据并随着时间的推移观察数字下降是非常重要的。

Another method of monitoring response to Ivermectin 1mg/kg/day treatment is to follow up with regular ultrasounds or CTs (or other types of diagnostic imaging)

另一种监测对Ivermectin每日1mg/kg治疗的反应的方法是定期进行超声检查或CT（或其他类型的诊断成像）。

This regimen would be taken daily until tumors disappear or cancer blood markers drop to normal range.

此方案将每天服用，直到肿瘤消失或癌症血液标记物下降到正常范围。

Typical Turbo Cancers: lymphomas, breast cancer, colon cancer, lung cancer, melanoma, testicular cancer, cervical cancer, ovarian cancer, kidney cancer.

典型的Turbo癌症：淋巴瘤、乳腺癌、结肠癌、肺癌、黑色素瘤、睾丸癌、宫颈癌、卵巢癌、肾癌。

 

HIGH DOSE:

高剂量：

2mg/kg/day is a high dose.

每天2mg/kg是一个高剂量。

I would start with this dose in aggressive Turbo Cancer cases where time is of the essence: Leukemia, Pancreatic Cancer, Brain cancers (glioblastoma, astrocytoma).

我会从这个剂量开始，适用于时间非常关键的激进的Turbo癌症病例：白血病、胰腺癌、脑癌（胶质母细胞瘤、星形细胞瘤）。

For brain cancers in particular the issue is getting sufficient IVM across the blood brain barrier to have an impact on brain tumors. So a higher dose is necessary.

对于脑癌特别是穿越血脑屏障以对脑肿瘤产生影响是一个问题。因此，需要更高的剂量。

Could be used for some rarer but aggressive Turbo Cancers such as: appendix, gallbladder, cholangiocarcinoma, angiosarcoma and other types of sarcoma.

可以用于一些较少见但激进的Turbo癌症，如：阑尾癌、胆囊癌、胆管癌、血管肉瘤和其他类型的肉瘤。

VERY HIGH DOSE:

非常高剂量：

2.5mg/kg/day is a very high dose with possibility of transient visual side effects.

每天2.5mg/kg是一个非常高的剂量，可能会出现短暂的视觉副作用。

The effect on cancer is likely similar to 2mg/kg/day, but if anyone is in a very desperate situation:

对癌症的影响可能与每天2mg/kg相似，但如果有人处于非常绝望的情况下：

• extensive burden of metastatic disease

  广泛的转移性疾病负担

• extremely aggressive or large brain tumors

  非常激进或大的脑肿瘤

• only days to live

  只剩下几天可以活

• extremely poor prognosis

  预后非常不好

it may be worth pushing the dose to this level.

将剂量提高到这个水平可能是值得的。

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Stage 4 Colon Cancer Case - Rick Alderson took Ivermectin with his Cancer Treatment (Epoch Times)

第四期结肠癌案例 - Rick Alderson在接受癌症治疗时服用Ivermectin（大纪元）

 

CONCLUSION:

结论：

In this article, I am not giving medical advice. I am not recommending a protocol or Ivermectin formulation, brand, source or dose.

在本文中，我没有提供医疗建议。我没有推荐特定的方案或Ivermectin配方、品牌、来源或剂量。

This is information based on peer reviewed research and some hypotheses and thought experiments in the interest of advancing science and medical knowledge.

这是基于同行评议的研究和一些假设和思想实验的信息，旨在推动科学和医学知识的发展。

 

注：Turbo cancer（涡轮癌） 是一个反疫苗接种说法，其核心理念是，接种了 COVID-19 疫苗（尤其是 mRNA 疫苗）的人患有快速发展的癌症的高发病率。

 

原文链接：https://makismd.substack.com/p/ivermectin-and-cancer-part-2-treating