Technical field

The present invention relates to compositions, particularly a kind of compositions and application thereof with acne-removal function.

Background technology

Acne popular name acne, comedo, be because a kind of dermatosis that hair follicle and sebaceous gland are blocked, inflammation caused, good sending out in vigorous positions of sebum secretion such as face, shirtfront and last backs mainly shows as hoary hair's acne, blackhead and inflammatory pimple, and serious can nodosity and cyst.Acne is the dermatosis of modal influence beauty treatment among the young crowd, and social mentality's problems such as sense of personal worth, self-confidence are impaired, awkward, depressed, anxiety appear in patient easily, cause social and the obstacle etc. of obtaining employment.At present, acne-eliminating cosmetic on the market is of a great variety, but cure rate is low mostly, outbreak repeatedly easily after the drug withdrawal, and mostly be chemicals and hormone medicine greatly, be easy to generate side effect after the use.Therefore, the development of efficient, safe acne-eliminating cosmetic is the urgent needs of patients with acne.

Artemisinin mother liquid is the residue after sweet wormwood herb extracts arteannuin.Arteannuin is to separate a kind of malaria effective ingredient that obtains from Herba Artemisiae Annuae, has been classified as the prefered method of treatment malaria by WHO based on the conjoint therapy of arteannuin; Scientists finds that also arteannuin and derivant thereof have selective toxicity to multiple cancerous cell in recent years.Though arteannuin can chemosynthesis, cost is very high, can't suitability for industrialized production, and present main source remains from sweet wormwood herb and extracts.The method of extracting arteannuin from Herba Artemisiae Annuae has multiple, and wherein the organic solvent extraction method is easy and simple to handle, with low cost, is the method that present most of producer extensively adopts.With leachings such as organic solvent such as petroleum ether, gasoline, cyclohexane extraction, ethyl acetate, the gained leaching liquid is isolated arteannuin through steps such as column chromatography for separation, condensing crystallizings to this method with artemisia leaf, and the residue extracting solution reclaims solvent and promptly gets artemisinin mother liquid.Bibliographical information contains arteannuin in the artemisinin mother liquid, Herba Artemisiae Annuae first, second, third, fourth, penta element, and artelinic acid, the artemisic acid methyl ester, volatile oil, flavonoid, Coumarins, oils, waxiness, multiple composition such as fat hydrocarbon has effects such as hemostasis, antiinflammatory, inhibition fungus.The use but the present great majority of artemisinin mother liquid go out of use or only act as a fuel causes the significant wastage of resource.

Shea butter (Shea Butter) is the oils and fats that extraction obtains from the kernel of the RUMUGUO tree that originates in Africa.Itself and the greasy every index of human body smegma are the most approaching, contain abundant non-saponification composition, can be rapidly by skin absorbs, have preserve moisture, effect such as sun-proof, defying age, antiinflammatory, dermatitis, eczema, sunburn, cold injury, scald, breach and scar skin etc. are had tangible promotion healing effect.

Up to now, Shang Weijian is the research report that primary raw material prepares acne-eliminating cosmetic with artemisinin mother liquid and shea butter.

Summary of the invention

In view of this, for overcoming the deficiencies in the prior art, the object of the present invention is to provide a kind of natural composition with acne-removal function, the energy Bergamot Mint Extract, remove aging cutin, dredging pore, bactericidal antiphlogistic, and can promote cell metabolism, repair impaired skin, remove seal, flat scar in anti-acne, life-time service can effectively suppress acne and generate, reduce healthy skin and safety non-toxic.

For reaching this purpose, the invention provides a kind of compositions with acne-removal function, form by following component by weight: 1～10 part of artemisinin mother liquid, 5～100 parts of shea butters.

Further, the weight proportion of each component is: 2～7 parts of artemisinin mother liquid, 5～70 parts of shea butters;

Further, described artemisinin mother liquid is obtained by following method:

A, with the artemisia leaf organic solvent extraction, extracting solution;

B, step a gained extracting solution is carried out column chromatography, arteannuin is adsorbed on the chromatographic column, the extract that is not adsorbed on the chromatographic column is removed in washing, collects cleaning mixture, reclaims solvent, mother solution I;

C, the arteannuin that is adsorbed on the chromatographic column among the step b is eluted, collect eluent, condensing crystallizing filters, respectively arteannuin coarse-grain and filtrate, filtrate is reclaimed solvent, mother solution II;

D, the mother liquid obtained II of the mother liquid obtained I of step b and step c is mixed, promptly get artemisinin mother liquid;

Further, described organic solvent is a petroleum ether.

Another object of the present invention is to provide described application with compositions of acne-removal function.

For reaching this purpose, the invention provides the described application of compositions in the preparation acne-eliminating cosmetic with acne-removal function.

Further, described have the compositions of acne-removal function and the cosmetics acceptable carrier is made various dosage forms according to conventional preparation method a acne-eliminating cosmetic.

Above-mentioned cosmetics acceptable carrier is meant the conventional carrier of cosmetic field, includes but not limited to: oily carrier such as oils and fats, wax class, hydro carbons, high fatty alcohol, higher fatty acids, esters etc.; Opaque carrier such as Pulvis Talci, Kaolin, bentonite, titanium dioxide, magnesium stearate, polyethylene powder, polystyrene powder, cellulose bead etc.; Colloid bearer such as gelatin, methylcellulose, ethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl-cellulose, Polyethylene Glycol, polyvinyl alcohol, polyvinylpyrrolidone, acrylate copolymer etc.; Surfactant such as anion surfactant, cationic surfactant, amphoteric surfactant and nonionic surfactant etc.; And wetting agent, binding agent, antiseptic, antioxidant, coloring agent and spice etc.Above-mentioned various dosage form is meant the regular dosage form of cosmetic field, includes but not limited to: water preparation, Emulsion, cream, gel, unguentum, face film agent etc.

Beneficial effect of the present invention is: the invention provides a kind of natural composition with acne-removal function, use confirmation through routine patients with acne up to a hundred, its energy Bergamot Mint Extract is removed aging cutin, dredging pore, bactericidal antiphlogistic, and can promote cell metabolism, repair impaired skin, in anti-acne, remove seal, flat scar, life-time service can effectively suppress acne and generate, and reduces healthy skin and safety non-toxic.With the present composition is active component, can make the acne-eliminating cosmetic of various dosage forms with one or more cosmetics acceptable carriers according to conventional preparation method, satisfies pressing for of vast patients with acne, has a good application prospect.In addition, depleted artemisinin mother liquid is turned waste into wealth in the present invention, fully recycles resource, can improve the economic and social benefits.

The specific embodiment

In order to make the purpose, technical solutions and advantages of the present invention clearer, below the preferred embodiments of the present invention are described in detail.

The shea butter of Shi Yonging is available from Ghana PURE LTD company in a preferred embodiment; Artemisinin mother liquid is made by following method available from Chongqing Holley Pharmaceutical limited company:

A, with the artemisia leaf crushed after being dried, get the artemisia leaf powder, add the petroleum ether merceration and extract, per petroleum ether that more renewed in 24 hours is colourless to extracting solution, merges multiple extraction liquid, is concentrated into proper volume, concentrated extracting solution;

B, step a gained concentrated extracting solution is carried out silica gel column chromatography, arteannuin is adsorbed on the chromatographic column, the extract that is not adsorbed on the chromatographic column is removed in washing, collects cleaning mixture, reclaims solvent, mother solution I;

C, the arteannuin that is adsorbed on the chromatographic column among the step b is eluted, collect eluent, condensing crystallizing filters, respectively arteannuin coarse-grain and filtrate, filtrate is reclaimed solvent, mother solution II;

D, the mother liquid obtained II of the mother liquid obtained I of step b and step c is mixed, promptly get artemisinin mother liquid.

The preparation of embodiment 1～5, anti-acne unguentum

Primary raw material and weight proportion: see Table 1.

The primary raw material of table 1, anti-acne unguentum and weight proportion

Preparation method: get artemisinin mother liquid, add 5 times of water gagings, be heated to temperature and make dissolving for 50 ℃, filter, get filtrate, standby; Get suitable quantity of water, add glycerol, polyoxyethylene ether phosphotriester and ethyl hydroxybenzoate, heating makes dissolving, adds the filtrate of above-mentioned artemisinin mother liquid again, and mix homogeneously is as water; Get shea butter, heating makes fusing, as oil phase; Water is slowly added in the oil phase, constantly be stirred to condensation, promptly get the anti-acne unguentum.

Using method: earlier cleaning is facial, again with anti-acne unguentum spot printing or spread on the acne place, every day 2～6 times.Concrete number of times is decided according to patient skin situation, acne position and the order of severity, needs usually to use 2～7 days, and severe case may need several weeks even longer time.

The anti-acne unguentum of the foregoing description 1～8 preparation is on probation through routine patients with acne up to a hundred, the result confirms: its energy Bergamot Mint Extract, remove aging cutin, dredging pore, bactericidal antiphlogistic, and can promote cell metabolism, repair impaired skin, in anti-acne, remove seal, flat scar, determined curative effect, the treatment effective percentage reaches more than 95%, and the patient untoward reaction all do not occur after using.

Certainly, except that unguentum, compositions of the present invention can also be made the serial acne-eliminating cosmetic of multiple dosage form with the cosmetics acceptable carrier according to conventional preparation method, as water preparation, Emulsion, cream, gel, face film agent etc., independent or supporting use, full face or affected part are local uses, and not only can reach the purpose for the treatment of acne efficiently and safely, can also effectively prevent the generation of acne.

Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although by invention has been described with reference to the preferred embodiments of the present invention, but those of ordinary skill in the art is to be understood that, can make various changes to it in the form and details, and the spirit and scope of the present invention that do not depart from appended claims and limited.

 

1, has the compositions of acne-removal function, it is characterized in that: form by following component by weight: 1～10 part of artemisinin mother liquid, 5～100 parts of shea butters.

2, the compositions with acne-removal function according to claim 1, it is characterized in that: the weight proportion of each component is: 2～7 parts of artemisinin mother liquid, 5～70 parts of shea butters.

3, the compositions with acne-removal function according to claim 1 and 2, it is characterized in that: described artemisinin mother liquid is obtained by following method:

A, with the artemisia leaf organic solvent extraction, extracting solution;

B, step a gained extracting solution is carried out column chromatography, arteannuin is adsorbed on the chromatographic column, the extract that is not adsorbed on the chromatographic column is removed in washing, collects cleaning mixture, reclaims solvent, mother solution I;

C, the arteannuin that is adsorbed on the chromatographic column among the step b is eluted, collect eluent, condensing crystallizing filters, respectively arteannuin coarse-grain and filtrate, filtrate is reclaimed solvent, mother solution II;

D, the mother liquid obtained II of the mother liquid obtained I of step b and step c is mixed, promptly get artemisinin mother liquid.

4, the compositions with acne-removal function according to claim 3 is characterized in that: described organic solvent is a petroleum ether.

5, the described application of compositions in the preparation acne-eliminating cosmetic of claim 1 with acne-removal function.

6, application according to claim 5 is characterized in that: described have the compositions of acne-removal function and the cosmetics acceptable carrier is made various dosage forms according to conventional preparation method a acne-eliminating cosmetic.

 

 

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